Adsorption of Cefocelis Hydrochloride on Macroporous Resin: Kinetics, Equilibrium, and Thermodynamic Studies

The adsorptions of Cefocelis hydrochloride in aqueous solution on macroporous resin (HP-20) were studied. On the basis of static experiments with HP-20 resin, the adsorption kinetics, isotherms, and thermodynamics of Cefocelis hydrochloride in aqueous solution on macroporous resin (HP-20) were investigated. Adsorption equilibrium data were correlated with the Langmuir and Freundlich equations. Adsorption data of kinetic were modeled using the Crank equation and fitting for the diffusion coefficient (D e), and the value of the liquid film mass transfer coefficient (k f) was estimated from Carberry equation. Dynamic adsorption was performed on HP-20 resin packed in a glass column to obtain optimal parameters. The initial concentration, bed height, and residence time were considered to determine the dynamic test for the breakthrough curve. The values of thermodynamic parameters including the isosteric adsorption enthalpy (ΔH), free energy (ΔG), entropy (ΔS), and adsorption activation energy (E a) demonstrated the process of adsorption was spontaneous and exothermic. The adsorption process was controlled by a physical mechanism.