Complex Polymer Nanoparticle Synthesis and Morphology Control Using an Inkjet Mixing System

Complex polymer nanoparticles were synthesized via a one-step antisolvent precipitation method using an inkjet mixing system. The effect of collision speed, impact parameter, and solution concentration on the product profiles was investigated. Taking advantage of the rapid mixing capability of an inkjet mixing system, the balance of the diffusion and stabilization rate was discussed, and the mechanism of morphology change in complex polymer nanoparticles was suggested. According to the suggested mechanism, it was demonstrated that the morphology was controllable by changing the mixing ratio of solvents and anti-solvents under rapid mixing. It was also demonstrated that the morphology and particle size of the complex polymer nanoparticles were controllable by changing the collision rate, impact parameter, and solution concentration, and Janus polymer nanoparticles were successfully synthesized with d av = 300 nm and CV = 0.2.