The parental origin of de novo X-autosome translocations in females with Duchenne muscular dystrophy revealed by M27ß methylation analysis

The parental origin of de novo X-autosome translocations in females with Duchenne muscular dystrophy revealed by M27ß methylation analysis

The parental origin of 3 de novo X-autosome translocations in females with Duchenne Muscular Dystrophy (DMD) was studied by means of methylation analysis using the X-linked probe M27ß. In all three the translocation was found to be paternal in origin. The parental origin of X-autosome translocations...

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Veröffentlicht in:Genetical Research 1990-10, Vol.56 (2-3), p.135-140
Hauptverfasser: Robinson, David O., Boyd, Yvonne, Cockburn, David, Collinson, Morag N., Craig, Ian, Jacobs, Patricia A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The parental origin of 3 de novo X-autosome translocations in females with Duchenne Muscular Dystrophy (DMD) was studied by means of methylation analysis using the X-linked probe M27ß. In all three the translocation was found to be paternal in origin. The parental origin of X-autosome translocations in females with and without DMD is compared with other structural abnormalities of the X and with autosomal translocations.
ISSN:0016-6723
1469-5073
DOI:10.1017/S0016672300035217