Copper alloys’ metal migration and bioaccessibility in saliva and gastric fluid

Copper alloys’ metal migration and bioaccessibility in saliva and gastric fluid

The oral bioaccessibility of copper alloys and pure metals was assessed using in vitro methods with synthetic saliva and gastric fluid. The metal-specific migration rates from polished alloy surfaces are higher in gastric (pH 1.5) than in saliva fluid (pH 7.2). In both media, migrations are higher f...

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Veröffentlicht in:Regulatory toxicology and pharmacology 2020-11, Vol.117, p.104754, Article 104754
Hauptverfasser: Delbeke, Katrien, Baken, Stijn, Simbor, Laia Perez, Rodriguez, Patricio H., Brouwers, Tony, Verougstraete, Violaine, Binks, Steve, Oller, Adriana, Danzeisen, Ruth, Gilles, Mik
Format: Artikel
Sprache:eng
Schlagworte:
Bioelution
Copper alloys
Metal migration
Metals
Oral bioaccessibility
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Zusammenfassung:The oral bioaccessibility of copper alloys and pure metals was assessed using in vitro methods with synthetic saliva and gastric fluid. The metal-specific migration rates from polished alloy surfaces are higher in gastric (pH 1.5) than in saliva fluid (pH 7.2). In both media, migrations are higher for lead than for other metals. The bioaccessible metal concentrations in massive copper alloys, after 2 h in gastric fluid, was only
ISSN:0273-2300
1096-0295
DOI:10.1016/j.yrtph.2020.104754