Biomarkers in the diagnosis of wounds infection: An analytical perspective

Infection is one of the most serious complications that can occur in wounds. Biomarkers can be used as a tool directly related to infection. So, herein current methods and new approaches for the determination of wound infection, based on biomarkers, were compared and discussed. In this review, it is highlighted the different enzymatic biomarkers related to wound infection, and how they can be used for early detection of the same. It also aims to compile the different analytical methods and describe the potential of each one. The global and critical analysis research made it possible to perceive that of all the biomarkers studied, the enzymes demonstrated great potential, through the comparison with all biomarkers, since they allow the detection of infection in very early stages, and so a previous diagnostic and treatment. •Early infection detection in wounds prevents progressing to serious conditions.•There are biomarkers that are directly related to wounds infection.•Enzymes are potential biomarkers as they appear early in the wound.•Developing analytical methods for enzyme detection are in progress and presented.•The fluorimetry is a common method to all enzymes and lead in relation to the LOD.