Synthesis of fluorine-containing α-alkyl-α-diazoesters and their utility in enantioselective cyclopropanation

[Display omitted] The synthesis and utilization of fluorine-containing α-alkyl-α-diazoesters has been reported. Access to fluoroalkyl cyclopropanes was achieved utilizing Rh2(S-PTTL)4 as a catalyst with good yields, enantioselectivities, and diastereoselectivities across a series of styrenes and α-alkyl-α-diazoesters. This study expands the accessibility of fluorine-containing building blocks for synthesis.