In(OTf)3-catalyzed oxygenative bifunctionalization of alkynes

[Display omitted] An In(OTf)3-catalyzed oxygenative bifunctionalization reaction has been developed for the facile synthesis of various α-functionalized ketones. A wide range of aryl sulfoxides and electron-rich arylalkynes prove to be suitable substrates for this transformation. The potential of ou...

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Veröffentlicht in:	Tetrahedron letters 2024-05, Vol.141, p.155074, Article 155074
Hauptverfasser:	Liu, Shiqing, Zhou, Ruize, Zhang, Miaofei, Chen, Chen, Chen, Xialei, Qian, Guoying, Rong, Zhouting
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Substituted quinolines Indium catalysis Oxygenative bifunctionalization α-Arylated ketones
Online-Zugang:	Volltext
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Zusammenfassung:	[Display omitted] An In(OTf)3-catalyzed oxygenative bifunctionalization reaction has been developed for the facile synthesis of various α-functionalized ketones. A wide range of aryl sulfoxides and electron-rich arylalkynes prove to be suitable substrates for this transformation. The potential of our method was then extended to the synthesis of 8-substituted quinolines from ynamides and quinoline-N-oxides.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2024.155074