Two new cytochalasins from Chaetomium sp. Strain

Two new cytochalasins from Chaetomium sp. Strain

[Display omitted] Two new compounds armochaetoglosin A1 (1) and armochaetoglosin A2 (2), together with three known compounds (3–5), were isolated from Chaetomium sp. Strain. Their structures were elucidated based on spectroscopic methods, including extensive NMR and MS spectra. Compound 5 showed pot...

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Veröffentlicht in:Tetrahedron letters 2024-03, Vol.137, p.154936, Article 154936
Hauptverfasser: Zhao, Miao, Xian, Xiao-Ya, Liang, Lin, Gao, Jin-Tao, Wang, Li-Sheng, Zhou, Xian-Li, Liang, Cheng-Qin
Format: Artikel
Sprache:eng
Schlagworte:
Chaetomium sp. Strain
Cytochalasin
Secondary metabolites
α-glucosidase
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Zusammenfassung:[Display omitted] Two new compounds armochaetoglosin A1 (1) and armochaetoglosin A2 (2), together with three known compounds (3–5), were isolated from Chaetomium sp. Strain. Their structures were elucidated based on spectroscopic methods, including extensive NMR and MS spectra. Compound 5 showed potential inhibitory activity on α-glucosidase with the IC50 value of 38.81 ± 8.08 µM. Molecular docking studies confirmed our result on compound 5α-glucosidase inhibitory properties.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2024.154936