A facile and catalyst-free microwave-promoted method for the synthesis of 3-trifluoromethyl 1,2,4-triazole-5-thiones

[Display omitted] Herein, a fast, simple, efficient, and eco-friendly procedure for the synthesis of 4-aryl-3-(trifluoromethyl)-1H-1,2,4-triazole-5(4H)-thiones under microwave irradiation is introduced. The current strategy enabled the synthesis of triazole-5(4H)-thiones scaffolds at 70 °C under shorter reaction times through the sequential nucleophilic addition and then intramolecular ring closing reactions between trifluoromethyl arylacetimidohydrazides and carbon disulfide in high yields.