Metal-free dearomative 2,3-difunctionalization of indoles via radical cascade

Metal-free dearomative 2,3-difunctionalization of indoles via radical cascade

[Display omitted] An oxidative dearomatization of protected indoles leading to 2-azido 3-arylselenyl indolines has been developed under metal-free conditions. The formation of CN and CSe bonds is believed to arise from the oxidation of indole via radical cascade. The reaction is regio and diastereo-...

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Veröffentlicht in:Tetrahedron letters 2023-05, Vol.121, p.154478, Article 154478
Hauptverfasser: Pal, Pranesh, Goud, Gadela Karteek, Sridhar, Balasubramanian, Mainkar, Prathama S., Nayani, Kiranmai, Chandrasekhar, Srivari
Format: Artikel
Sprache:eng
Schlagworte:
Dearomatization
Diastereoselective
Difunctionalization
Indolines
Metal-free
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Zusammenfassung:[Display omitted] An oxidative dearomatization of protected indoles leading to 2-azido 3-arylselenyl indolines has been developed under metal-free conditions. The formation of CN and CSe bonds is believed to arise from the oxidation of indole via radical cascade. The reaction is regio and diastereo-selective and works under mild conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2023.154478