Deracemisation of racemic 2-substituted indolines by monoamine oxidase from Pseudomonas monteilii ZMU-T01
[Display omitted] •A new function of monoamine oxidase (MAO-5) was found.•Bio-mediated oxidative resolution of racemic 2-substituted indolines was developed.•(R)-2-methyl-indoline and its derivates was obtained with high enantioselectivity by biocatalytic process. Monoamine oxidase strain (MAO-5) fr...
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Veröffentlicht in: | Tetrahedron letters 2022-12, Vol.113, p.154249, Article 154249 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | [Display omitted]
•A new function of monoamine oxidase (MAO-5) was found.•Bio-mediated oxidative resolution of racemic 2-substituted indolines was developed.•(R)-2-methyl-indoline and its derivates was obtained with high enantioselectivity by biocatalytic process.
Monoamine oxidase strain (MAO-5) from Pseudomonas monteilii ZMU-T01 mediated oxidative resolution of racemic 2-substituted indolines has been successfully described. A series of highly enantioselective 2-substituted indoline derivatives were obtained in up to 50 % conversion and >99 % ee. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2022.154249 |