CuBr2 catalyzed alkynylation of tertiary methylamine with terminal alkyne using aqueous TBHP under mild conditions

CuBr2 catalyzed alkynylation of tertiary methylamine with terminal alkyne using aqueous TBHP under mild conditions

[Display omitted] A CuBr2 catalyzed alkynylation of tertiary methylamines with terminal alkynes has been developed. Compared with the recent alkenylations, which mostly focused on aromatic methylamines, this transformation shows good reactivity to aliphatic tertiary methylamines. The reaction procee...

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Veröffentlicht in:Tetrahedron letters 2022-10, Vol.109, p.154136, Article 154136
Hauptverfasser: Yang, Hui, Sun, Zetian, Chen, Huimin, Mao, Fenghua, Li, Xiaoqing, Xu, Xiangsheng
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic tertiary methylamine
Alkynylation
Copper-catalysis
Propargylamine
Terminal alkyne
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Zusammenfassung:[Display omitted] A CuBr2 catalyzed alkynylation of tertiary methylamines with terminal alkynes has been developed. Compared with the recent alkenylations, which mostly focused on aromatic methylamines, this transformation shows good reactivity to aliphatic tertiary methylamines. The reaction proceeds under room temperature using aqueous TBHP without the requirement of an inert atmosphere.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.154136