Asymmetric syntheses of (–)-hedyosumins A–C via enantioselective Diels–Alder reaction of (E)-Hex-3-en-5-yn-2-one and platinum(II)-catalyzed [3+2]-cyclization

Asymmetric syntheses of (–)-hedyosumins A–C via enantioselective Diels–Alder reaction of (E)-Hex-3-en-5-yn-2-one and platinum(II)-catalyzed [3+2]-cyclization

[Display omitted] Enantioselective construction of the central [3.2.1] oxa-bicyclic core of hedyosumins A–C was achieved via an enantioselective Diels–Alder reaction and a platinum(II)-catalyzed 1,3-dipolar [3+2] cycloaddition as key steps, which leads to the asymmetric total synthesis of hedyosumin...

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Veröffentlicht in:Tetrahedron letters 2022-07, Vol.102, p.153946, Article 153946
Hauptverfasser: Wang, Kuang-Yu, Li, Yuanhe, Zhang, Shu-Lei, Chen, Jia-Hua, Yang, Zhen
Format: Artikel
Sprache:eng
Schlagworte:
1,3-dipolar [3+2] cycloaddition
Asymmetric
Diels–Alder reaction
hedyosumins A-C
Total synthesis
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Zusammenfassung:[Display omitted] Enantioselective construction of the central [3.2.1] oxa-bicyclic core of hedyosumins A–C was achieved via an enantioselective Diels–Alder reaction and a platinum(II)-catalyzed 1,3-dipolar [3+2] cycloaddition as key steps, which leads to the asymmetric total synthesis of hedyosumins A-C.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153946