Efficient thiocyanation of aromatic compounds using NH4SCN, DMSO and H2SO4

Efficient thiocyanation of aromatic compounds using NH4SCN, DMSO and H2SO4

[Display omitted] A simple, efficient, and smooth thiocyanation of indoles, phenols and aniline derivatives using NH4SCN, DMSO and H2SO4 in DMF is introduced. Using this procedure, diverse indoles and N-alkyl indoles are selectively thiocyanated at the C-3 position. para-free anilines, N-alkyl anili...

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Veröffentlicht in:Tetrahedron letters 2022-07, Vol.101, p.153929, Article 153929
Hauptverfasser: Abbasi, Mohammad, Nowrouzi, Najmeh, Sedaghat, Hamed
Format: Artikel
Sprache:eng
Schlagworte:
Aniline
DMSO
Indole
Phenol
Thiocyanation
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Zusammenfassung:[Display omitted] A simple, efficient, and smooth thiocyanation of indoles, phenols and aniline derivatives using NH4SCN, DMSO and H2SO4 in DMF is introduced. Using this procedure, diverse indoles and N-alkyl indoles are selectively thiocyanated at the C-3 position. para-free anilines, N-alkyl anilines and phenols undergo thiocyanation at the para position selectively.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153929