Synthesis of hybrid thiohemicucurbiturils

[Display omitted] •A method for synthesis of hybrid thiohemicucurbiturils has been efficiently developed.•Some carbonyl groups at the portal position of hemicucurbituril are replaced by thiono group.•Contrary to the acid condition for synthesis of traditional hemicucurbiturls, this method provides a moderate condition without acid and base.•This method provides a potential platform for modular synthesis of novel hybrid hemicucurbiturl derivatives with various motifs. A method for synthesis of hybrid thiohemicucurbiturils has been developed. With this method, three novel thiohemicucurbiturils have been constructed. Contrary to the acid condition for synthesis of traditional hemicucurbiturls, this method provides a moderate condition which is compatible for more complicated structure in synthesis of novel hybrid hemicucurbiturils.