Copper-catalyzed oxidative cross-dehydrogenative coupling (CDC) reaction of alcohols with secondary phosphine oxides

Copper-catalyzed oxidative cross-dehydrogenative coupling (CDC) reaction of alcohols with secondary phosphine oxides

[Display omitted] A copper-catalyzed oxidative cross-dehydrogenative coupling (CDC) strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was proposed. Under the mild reaction conditions (CuCl2·2H2O/K2S2O8, at room temperature for 3–12 h under air), a va...

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Veröffentlicht in:Tetrahedron letters 2022-06, Vol.99, p.153822, Article 153822
Hauptverfasser: Hua, Yingxiang, Lin, Yanchao, Chen, Wenyi, Ye, Liyi, Yin, Yingwu, Gao, Yuxing, Tu, Song
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
P[sbnd]O bond formation
Phosphinate esters
Secondary phosphine oxides
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Zusammenfassung:[Display omitted] A copper-catalyzed oxidative cross-dehydrogenative coupling (CDC) strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was proposed. Under the mild reaction conditions (CuCl2·2H2O/K2S2O8, at room temperature for 3–12 h under air), a variety of substrates were well-tolerated and afforded the desirable compounds in moderate to excellent yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153822