Metal-free synthesis of 5-trifluoromethyltetrazoles

Metal-free synthesis of 5-trifluoromethyltetrazoles

[Display omitted] An efficient transition-metal-free method for the synthesis of 5-trifluoromethyltetrazoles from arenediazonium tetrafluoroborates is reported, which relies on the use of trifluoroacetaldehyde N-tosylhydrazone as a convenient 2,2,2-trifluorodiazoethane source. The reaction proceeds...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2022-04, Vol.95, p.153717, Article 153717
Hauptverfasser: Lin, Xi, Luo, Beibei, He, Wenqin, Lu, Qingkai, Li, Longjia, Zheng, Huirong, Wu, Wei, Weng, Zhiqiang
Format: Artikel
Sprache:eng
Schlagworte:
Cycloaddition
Fluorine
Metal-free
Tetrazole
Trifluormethylation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:[Display omitted] An efficient transition-metal-free method for the synthesis of 5-trifluoromethyltetrazoles from arenediazonium tetrafluoroborates is reported, which relies on the use of trifluoroacetaldehyde N-tosylhydrazone as a convenient 2,2,2-trifluorodiazoethane source. The reaction proceeds in good to excellent yields and shows a high functional group tolerance.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153717