A concise synthesis of indolo[2,1-a]isoquinoline via alkyne annulations promoted by base

A concise synthesis of indolo[2,1-a]isoquinoline via alkyne annulations promoted by base

[Display omitted] A convenient and one-pot synthetic method for the construction of indolo[2,1-a]isoquinolines is developed by the dehydrative cyclocondensation reactions of the easily available 2-hydroxymethyl anilines with 2-ethynylbenzaldehydes in DMSO in the presence of KOH and TBAI under air.

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2022-01, Vol.88, p.153566, Article 153566
Hauptverfasser: Mehmood, Hina, Iqbal, Muhammad Asif, Hua, Ruimao
Format: Artikel
Sprache:eng
Schlagworte:
Alkyne
Annulation
Base-promoted
Indolo[2,1-a]isoquinoline
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Beschreibung
Zusammenfassung:[Display omitted] A convenient and one-pot synthetic method for the construction of indolo[2,1-a]isoquinolines is developed by the dehydrative cyclocondensation reactions of the easily available 2-hydroxymethyl anilines with 2-ethynylbenzaldehydes in DMSO in the presence of KOH and TBAI under air.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153566