Cyperensol A, a novel sesquiterpenoid with a unique 6/6/5 skeleton from Cyperus rotundus L

Cyperensol A, a novel sesquiterpenoid with a unique 6/6/5 skeleton from Cyperus rotundus L

[Display omitted] A novel sesquiterpenoid, named Cyperensol A (1), was isolated from the rhizomes of Cyperus rotundus L. Its structure was elucidated extensively by the spectroscopic analysis. Possible biosynthetic pathway of 1 was proposed. Compound 1 showed inhibitory activity on IL-6 induced acti...

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Veröffentlicht in:Tetrahedron letters 2021-12, Vol.87, p.153543, Article 153543
Hauptverfasser: Wang, Qiang, Lou, Jia-hao, Zhao, Zi-yan, Duan, Wen-lan, Wang, Ji-hong, Zeng, Guang-zhi, Yin, Jun-lin
Format: Artikel
Sprache:eng
Schlagworte:
Cyperensol A
Cyperus rotundus L
Inhibitor
JAK/STAT3 signaling pathway
Sesquiterpenoid
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Zusammenfassung:[Display omitted] A novel sesquiterpenoid, named Cyperensol A (1), was isolated from the rhizomes of Cyperus rotundus L. Its structure was elucidated extensively by the spectroscopic analysis. Possible biosynthetic pathway of 1 was proposed. Compound 1 showed inhibitory activity on IL-6 induced activation of JAK/STAT3 signaling pathway with IC50 value of 189.37 ± 7.20 μM.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153543