Fluoroethylthiolation of indoles with iodofluoroethane

Fluoroethylthiolation of indoles with iodofluoroethane

[Display omitted] The direct fluoroethylthiolation of indoles with iodofluoroethane was developed. The new unexplored CHxFyCH2I/Na2S2O4/PPh3 system proceeded under mild condition to afford the relevant fluoroethylthiolated indoles from good to excellent yield. The simple and efficient strategy offer...

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Veröffentlicht in:Tetrahedron letters 2021-11, Vol.85, p.153488, Article 153488
Hauptverfasser: Leng, Faqiang, Huang, Jianjian, Yu, Nianhua, Wang, Guizhao
Format: Artikel
Sprache:eng
Schlagworte:
Fluoroethylthiolation
Indole
Iodofluoroethane
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Zusammenfassung:[Display omitted] The direct fluoroethylthiolation of indoles with iodofluoroethane was developed. The new unexplored CHxFyCH2I/Na2S2O4/PPh3 system proceeded under mild condition to afford the relevant fluoroethylthiolated indoles from good to excellent yield. The simple and efficient strategy offers exciting opportunities for the discovery of fluoroalkylthiol moiety introduction.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153488