Metal-free C3 α-aminoalkylation of quinoxalin-2(1H)-ones with amines

Metal-free C3 α-aminoalkylation of quinoxalin-2(1H)-ones with amines

The first C3 α-aminoalkylation of quinoxalin-2(1H)-ones with amines under mild conditions. [Display omitted] An efficient method was developed for the synthesis of various C3 α-aminoalkylated quinoxalin-2(1H)-ones via Cross-Dehydrogenative Coupling under transition-metal-free conditions, affording t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2021-11, Vol.84, p.153439, Article 153439
Hauptverfasser: Jiang, Xinpeng, Du, Xiaofan, Chen, Keda, Han, Hang, Xu, Di, Zhu, Binbing, Jiang, Le, Fang, Liyun, Yu, Chuanming
Format: Artikel
Sprache:eng
Schlagworte:
Aminoalkylation
Cross-Dehydrogenative Coupling
Quinoxalin-2(1H)-one
Radical Chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The first C3 α-aminoalkylation of quinoxalin-2(1H)-ones with amines under mild conditions. [Display omitted] An efficient method was developed for the synthesis of various C3 α-aminoalkylated quinoxalin-2(1H)-ones via Cross-Dehydrogenative Coupling under transition-metal-free conditions, affording the target products with a broad substrate scope in moderate to good yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153439