Copper-Catalyzed Heck-Type Couplings of Sulfonyl Chlorides with Olefins: Efficient and Rapid Access to Vinyl Sulfones

Copper-Catalyzed Heck-Type Couplings of Sulfonyl Chlorides with Olefins: Efficient and Rapid Access to Vinyl Sulfones

[Display omitted] A copper-catalyzed redox-neutral alkene sulfonylation reaction has been developed. This reported protocol can be easily scale up to a gram scale, and smoothly applied to the late-stage modification of several bioactive molecules.

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Veröffentlicht in:Tetrahedron letters 2021-09, Vol.80, p.153319, Article 153319
Hauptverfasser: Liu, Lixia, Xue, Pan, Chen, Qiulin, Wang, Chengming
Format: Artikel
Sprache:eng
Schlagworte:
Copper
Heck coupling
Redox-neutral
Sulfone
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Beschreibung
Zusammenfassung:[Display omitted] A copper-catalyzed redox-neutral alkene sulfonylation reaction has been developed. This reported protocol can be easily scale up to a gram scale, and smoothly applied to the late-stage modification of several bioactive molecules.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153319