Thiourea catalyzed 1,6-conjugate addition of indoles to para-quinone methides

Thiourea catalyzed 1,6-conjugate addition of indoles to para-quinone methides

[Display omitted] An efficient thiourea catalyzed 1,6-conjugate addition of indoles to para-quinone methides (p-QMs) was developed. p-QMs was activated by a weak hydrogen-bond effect. The reaction is featured mild reaction conditions and wide substrate scope. A series of C-3 bisaryl methine substitu...

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Veröffentlicht in:Tetrahedron letters 2021-09, Vol.81, p.153315, Article 153315
Hauptverfasser: Wu, Guangmiao, Li, Tao, Liu, Fuhai, Zhao, Yulong, Ma, Shiqiang, Tang, Shouchu, Xie, Xingang, She, Xuegong
Format: Artikel
Sprache:eng
Schlagworte:
1,6-Conjugate addition
Indole
Organocatalysis
para-Quinone methides
Thiourea
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Zusammenfassung:[Display omitted] An efficient thiourea catalyzed 1,6-conjugate addition of indoles to para-quinone methides (p-QMs) was developed. p-QMs was activated by a weak hydrogen-bond effect. The reaction is featured mild reaction conditions and wide substrate scope. A series of C-3 bisaryl methine substituted indoles are prepared in high yield.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153315