A facile synthesis of meta- and para-terphenylglyoxamide-based peptidomimetics

[Display omitted] •A simple and efficient procedure for thesynthesis of meta- and para-substituted terphenyl compounds.•A facile synthesis of novel 5-biphenyl substituted N-acylisatins.•Versatile and robust synthesis of terphenylglyoxamides under mild conditions. A series of meta- and para-terphenylglyoxamide peptidomimetics have been synthesised by the ring-opening of 5-(biphenylyl)-N-acylisatins with alcohols, amines and amino acid methyl esters. The starting 5-(biphenylyl)isatins were synthesised via the Suzuki-Miyaura coupling reaction in a convenient and efficient manner.