Synthesis of new azapolycyclic scaffolds via the domino aminolysis of dicyclopentadiene diepoxide in water

[Display omitted] •First reported synthesis of the octahydro-1H-2,5-epimino-4,7-methanoindene azapolycyclic system.•Operationally simple method using water as the solvent.•2D NMR and XRD spectra of the products were studied in detail. A convenient method is reported for the multigram scale synthesis of compounds containing the novel octahydro-1H-2,5-epimino-4,7-methanoindene azapolycyclic system in good yields. This method involves the domino aminolysis of readily available dicyclopentadiene diepoxide in water at 165 °C. 2D NMR and XRD spectra of the products were studied in detail.