Efficient synthesis of sulfonylguanidines via reaction of tetra-substituted urine with ArSO2NCO

[Display omitted] •A one-step synthesis of sulfonylguanidines from urines with ArSO2NCO.•This reaction is compatible with various substrates.•This method has been developed with good yields.•The operation is very simple and convenient.•This method will be of broad interest to synthetic and mechanistic chemists. An efficient synthesis of sulfonylguanidines via reaction of tetra-substituted urines with ArSO2NCO has been developed with good yields, which provides a convenient way for synthesis of sulfonyl group protected guanidine from urine in one step.