Synthesis of tris-tertiary amine CycloTriVeratrilene (TACTV) derivatives as water soluble pre-organized three aromatic ring containing molecular scaffolds for the construction of protein mimics

[Display omitted] •Synthesis of water soluble highly pre-organized tris-tertiary amine CycloTriVeratrilene derivatives.•Synthesis of water soluble several aromatic ring containing compounds.•A semi-orthogonally protected molecular scaffold for introduction of different moieties.•One pot five step synthesis of three different cyclized peptides toward protein mimics. The synthesis of water soluble highly pre-organized Tris-tertiary Amine CycloTriVeratrilene (TACTV) derivatives was developed. A semi-orthogonally protected derivative allowed one pot sequential introduction of different peptide loops toward the molecular construction of synthetic antibody protein mimics.