Synthesis of substituted 2-aminobenzoxazoles via copper-catalyzed intramolecular N-arylation of iodophenol and amine-trichloroacetonitrile adduct under ultrasound-irradiation

The synthesis of substituted 2-aminobenzoxazoles via a one-pot, three-component, intramolecular cyclization of iodophenol and amine-trichloroacetonitrile adduct catalyzed by copper(I) iodide in MeCN under ultrasound irradiation at room temperature was achieved with good yields. The use of simple and readily available starting materials, no column chromatography, copper-catalyst, short reaction times, good yields (72–88 %), and applying the sonochemistry, are specifications of this protocol. [Display omitted] •Novel protocols synthesis of 2-aminobenzoxazoles.•CuI catalyzed and efficient sonochemical method in the synthesis of 2-aminobenzoxazoles.•N-Arylation of iodophenol and amine-trichloroacetonitrile adduct.