A green one-pot process for the synthesis of 1,2,4-triazole-fused heterocycles using FeBr3 catalyst and hydrogen peroxide

An environmentally benign oxidative cyclization utilizing FeBr3 catalyst and hydrogen peroxide as terminal oxidant is devised for one-pot synthesis of 1,2,4-triazole-fused heterocycles from commercially available aliphatic or (hetero)aromatic aldehydes and 2-hydrazinopyridine derivatives. The protocol features mild conditions, simple operation, air/water tolerance, short reaction time, and waste prevention, and has been demonstrated by the synthesis of 32 examples of 1,2,4-triazole-fused heterocycles bearing different substituents in moderate to excellent yields. To create your abstract, type over the instructions in the template box below.Fonts or abstract dimensions should not be changed or altered. [Display omitted]