Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor

Herein we disclose a deoxyfluorination of alcohols with an electrophilic fluorine source via visible-light photoredox catalysis. This radical-mediated C–F coupling is capable of fluorinating secondary and tertiary alcohols efficiently, complementing previously reported nucleophilic deoxyfluorination...

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Veröffentlicht in:	Tetrahedron 2023-07, Vol.141, p.133494, Article 133494
Hauptverfasser:	González-Esguevillas, María, Miró, Javier, Jeffrey, Jenna L., MacMillan, David W.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyfluorination Fluoroalkanes Oxalates Photoredox
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Herein we disclose a deoxyfluorination of alcohols with an electrophilic fluorine source via visible-light photoredox catalysis. This radical-mediated C–F coupling is capable of fluorinating secondary and tertiary alcohols efficiently, complementing previously reported nucleophilic deoxyfluorination protocols. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2023.133494