Practical synthesis of 5H-pyrido[2′,1:2,3]imidazo[4,5-b]indoles by Cu-catalyzed double C–N coupling reactions

Practical synthesis of 5H-pyrido[2′,1:2,3]imidazo[4,5-b]indoles by Cu-catalyzed double C–N coupling reactions

Fluorescent active small molecules containing 5H-pyrido [12′,1′:2,3]imidazo [4,5-b]indole core could be successfully prepared by Cu-catalyzed double C–N coupling reaction from 3-bromo-2-(2-bromophenyl)imidazo [1,2-a]pyridine with different amines in high yields. DMSO, a green solvent played a key ro...

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Veröffentlicht in:Tetrahedron 2023-04, Vol.136, p.133360, Article 133360
Hauptverfasser: Van Phuc, Ban, Dinh, Quang Huy, Chi, Nguyen Linh, Nguyen, Quyet Tien, Nga Truong, Thi Thanh, Van Tuyen, Nguyen, Nguyen, Hien, Langer, Peter, Dang, Tuan Thanh, Hung, Tran Quang
Format: Artikel
Sprache:eng
Schlagworte:
5H-pyrido[2′,1′:2,3]imidazo[4,5-b]indoles
Copper catalysis
C–N coupling
Ullmann reaction
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Zusammenfassung:Fluorescent active small molecules containing 5H-pyrido [12′,1′:2,3]imidazo [4,5-b]indole core could be successfully prepared by Cu-catalyzed double C–N coupling reaction from 3-bromo-2-(2-bromophenyl)imidazo [1,2-a]pyridine with different amines in high yields. DMSO, a green solvent played a key role for the success of this double C–N coupling reaction. This method may find potential applications not only in pharmaceutical chemistry but also in materials science. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2023.133360