Halogen-free oxidation of aryl ketones and benzyl nitrile derivatives to corresponding carboxylic acids by using NaOH/ TBHP in aqueous medium

Halogen-free oxidation of aryl ketones and benzyl nitrile derivatives to corresponding carboxylic acids by using NaOH/ TBHP in aqueous medium

Using inexpensive NaOH as the base and aq. TBHP (70%) as the oxidant, we have developed an efficient oxidative methodology for converting aryl ketones and benzyl nitrile derivatives to their corresponding acids in good yields. Several industrially relevant carboxylic acids could be easily synthesize...

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Veröffentlicht in:Tetrahedron 2023-04, Vol.136, p.133359, Article 133359
Hauptverfasser: Jaiswal, Arvind Kumar, Kushawaha, Ajay Kishor, Pandey, Shubham, Kumar, Abhishek, Sashidhara, Koneni V.
Format: Artikel
Sprache:eng
Schlagworte:
Eco-friendly
Effective
Furan dicarboxylic acid
Inexpensive
Oxidative methodology
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Zusammenfassung:Using inexpensive NaOH as the base and aq. TBHP (70%) as the oxidant, we have developed an efficient oxidative methodology for converting aryl ketones and benzyl nitrile derivatives to their corresponding acids in good yields. Several industrially relevant carboxylic acids could be easily synthesized in gram scale using this protocol. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2023.133359