Cyclic guanidine containing amino acids that promote glucocerebrosidase

Cyclic guanidine containing amino acids that promote glucocerebrosidase

Novel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from l-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase...

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Veröffentlicht in:Tetrahedron 2022-09, Vol.123, p.132959, Article 132959
Hauptverfasser: Al-Taie, Zahraa S., Bartholomew, Barbara, Coles, Simon J., Evans, Daniel M., Hollinshead, Jackie, Jones, Leigh F., Kraehenbuehl, Rolf, Murphy, Patrick J., Nash, Robert J., Penkova, Yana B., Tizzard, Graham J.
Format: Artikel
Sprache:eng
Schlagworte:
Cyclic guanidines
Glycosidase inhibitors
Glycosidase promoters
N-methylation
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Zusammenfassung:Novel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from l-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2022.132959