Ritter reaction for the synthesis of picolinamides

Ritter reaction for the synthesis of picolinamides

The synthesis of picolinamides through Ritter reaction of 2-cyanopyridine with alcohols and alkenes is reported. Moreover, a range of additional heteroaryl nitriles successfully participate in the amidation reaction. Salient features of the reaction include the operational simplicity and the inexpen...

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Veröffentlicht in:Tetrahedron 2022-09, Vol.122, p.132937, Article 132937
Hauptverfasser: Schreib, Benedikt S., Margarini, Jacopo, Carreira, Erick M.
Format: Artikel
Sprache:eng
Schlagworte:
Amidation
C–H Activation
Palladium
Picolinamides
Ritter reaction
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Zusammenfassung:The synthesis of picolinamides through Ritter reaction of 2-cyanopyridine with alcohols and alkenes is reported. Moreover, a range of additional heteroaryl nitriles successfully participate in the amidation reaction. Salient features of the reaction include the operational simplicity and the inexpensive reagents used. The synthetic utility of a camphene derived picolinamide is demonstrated through a palladium-catalyzed C–H arylation reaction. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2022.132937