Copper catalyzed synthesis of 3-((arylethynyl)selanyl)-1H-indoles via selenium insertion reaction by using elemental selenium

Here we disclosed an efficient and simple strategy for the synthesis of biologically relevant 3-((arylethynyl)selanyl)-1H-indoles. The reactions were carried out in presence of a catalytic amount of copper (I) bromide. The selenide adduct tolerates all types of substrates used. Furthermore, all the products were obtained at good to excellent yields. Unique coupling, multicomponent, one-pot access served a useful output in organic synthesis design. [Display omitted]