Substrate-dependent regiodivergent three-component condensation of 1H-pyrrole-2,3-diones, malononitrile and 4-hydroxyquinolin-2(1H)-ones

Substrate-dependent regiodivergent three-component condensation of 1H-pyrrole-2,3-diones, malononitrile and 4-hydroxyquinolin-2(1H)-ones

An efficient regiodivergent three-component condensation of 1H-pyrrole-2,3-diones, malononitrile, and 4-hydroxyquinolin-2(1H)-ones was developed. The reaction can lead to the formation of spiro[pyrano[3,2-c]quinoline-4,3′-pyrrole] derivatives or the substituted 1,5-dihydropyrrole-2-ones depending on...

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Veröffentlicht in:Tetrahedron 2021-05, Vol.88, p.132129, Article 132129
Hauptverfasser: Salnikova, Tatyana V., Sabitov, Andrey A., Dmitriev, Maksim V., Maslivets, Andrey N., Rubin, Michael
Format: Artikel
Sprache:eng
Schlagworte:
1H-pyrrole-2,3-dione
Condensation
Enols
Malononitrile
Regiodivergent reaction
Three-component reaction
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Zusammenfassung:An efficient regiodivergent three-component condensation of 1H-pyrrole-2,3-diones, malononitrile, and 4-hydroxyquinolin-2(1H)-ones was developed. The reaction can lead to the formation of spiro[pyrano[3,2-c]quinoline-4,3′-pyrrole] derivatives or the substituted 1,5-dihydropyrrole-2-ones depending on the substituents of 1H-pyrrole-2,3-diones and reaction conditions. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2021.132129