Exploiting C–H borylation for the multidirectional elaboration of 2-halopyridines

Regioselectively polysubstituted pyridines can be efficiently accessed from 2-halopyridines via a sequence involving C–H borylation, Suzuki-Miyaura cross-coupling and nucleophilic aromatic substitution chemistry. [Display omitted] •C–H borylation of 2-halopyridines is fast and efficient.•Cross coupling of 2-halopyridyl boronates is selective and efficient.•2-Halogen substituent can be substituted by a diverse set of nucleophile.•Sequence can be run in single pot mode with little loss in overall yield.