A novel reaction-based fluorescence probe for rapid imaging of HClO in live cells, animals, and injured liver tissues

Hypochlorous acid (HClO) is an important bioactive molecule, playing vital roles in a large number of physiological and pathological processes. Abnormal concentration of HClO in vivo has close contact with many diseases including inflammatory diseases and cancer. For bioimaging HClO, a new colorimet...

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Veröffentlicht in:	Talanta (Oxford) 2020-08, Vol.215, p.120901, Article 120901
Hauptverfasser:	Deng, Yingzhen, Feng, Shumin, Xia, Qingfeng, Gong, Shengyi, Feng, Guoqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Fluorescent Dyes - chemistry HClO HeLa Cells Humans Hypochlorous Acid - administration & dosage Hypochlorous Acid - analysis Hypochlorous Acid - metabolism In vivo imaging Injured liver tissues Liver - chemistry Liver - diagnostic imaging Liver - metabolism MCF-7 Cells Mice Mice, Inbred Strains Molecular Structure Near-infrared fluorescent probe Optical Imaging Particle Size Surface Properties Zebrafish
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Zusammenfassung:	Hypochlorous acid (HClO) is an important bioactive molecule, playing vital roles in a large number of physiological and pathological processes. Abnormal concentration of HClO in vivo has close contact with many diseases including inflammatory diseases and cancer. For bioimaging HClO, a new colorimetric and turn-on near-infrared (NIR) fluorescence probe (DDAO-ClO) was designed and synthesized in this work through a specific reaction of HClO with dimethylthiocarbamate. DDAO-ClO proved to show distinct and highly selective colorimetric and NIR fluorescence responses for HClO with fast response time (
ISSN:	0039-9140 1873-3573
DOI:	10.1016/j.talanta.2020.120901