Emerging prospects of integrated bioanalytical systems in neuro-behavioral toxicology
Neurotoxicity effects of industrial contaminants are currently significantly under investigated and require innovative analytical approaches to assess health and environmental risks at individual, population and ecosystem levels. Behavioral changes assessed using small aquatic invertebrates as stand...
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Veröffentlicht in: | The Science of the total environment 2021-02, Vol.756, p.143922, Article 143922 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Neurotoxicity effects of industrial contaminants are currently significantly under investigated and require innovative analytical approaches to assess health and environmental risks at individual, population and ecosystem levels. Behavioral changes assessed using small aquatic invertebrates as standard biological indicators of the aggregate toxic effects, have been broadly postulated as highly integrative indicators of neurotoxicity with physiological and ecological relevance. Despite recent increase in understanding of the emerging value of behavioral biotests, their wider implementation especially in high-throughput environmental risk assessment assays, is largely limited by the lack of advances in analytical technologies. To date, most of the behavioral biotests have only been performed with larger-volumes and lacked dynamic flow-through conditions. They also lack features necessary for development of higher throughput neuro-behavioral ecotoxicity assays such as miniaturization and integration of automated components. We postulate that some contemporary analytical limitations can be effectively addressed by innovative Lab-on-a-Chip (LOC) technologies, an emerging and multidisciplinary field poised to bring significant miniaturization to aquatic ecotoxicity testing. Recent developments in this emerging field demonstrate particular opportunities to study a plethora of behavioral responses of small model organisms in a high-throughput fashion. In this review, we highlight recent advances in this budding new interdisciplinary field of research. We also outline the existing challenges, barriers to development and provide a future outlook in the evolving field of neurobehavioral ecotoxicology.
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•Neurotoxicity of contaminants is currently significantly under investigated.•Small aquatic organisms can be used for a plethora of neuro-behavioral assays.•Implementation of advanced neuro-behavioral tests is just emerging.•Advanced behavioral tests require next-generation analytical innovations.•Integrated opto-fluidic systems can bring groundbreaking analytical advances. |
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ISSN: | 0048-9697 1879-1026 |
DOI: | 10.1016/j.scitotenv.2020.143922 |