Different techniques for overlapped UV spectra resolution of some co-administered drugs with paracetamol in their combined pharmaceutical dosage forms

Six simple, specific, accurate and precise spectrophotometric methods were developed for the first time analysis of some co-administered drugs with paracetamol in their mixture form without prior separation. Paracetamol & orphenadrine citrate were determined by using dual wavelength, bivariate, ratio difference, ratio derivative and mean centering of ratio spectra methods. Paracetamol & caffeine were determined by using ratio difference, ratio derivative and mean centering of ratio spectra methods. Paracetamol & diclofenac sodium were determined by using advanced absorption subtraction, ratio difference, ratio derivative and mean centering of ratio spectra methods. All of these methods were validated according to ICH guidelines where accuracy, precision, repeatability and robustness were found to be within the accepted limits. Advantages and limitations of each method are demonstrated and statistical comparison between the proposed methods was performed. Six spectrophotometric methods can be used to resolve the overlapping of some co-administered drugs with paracetamol such as paracetamol & orphenadrine citrate, paracetamol & caffeine and paracetamol & diclofenac sodium. Overlapping spectra of some co-administered drugs with paracetamol. [Display omitted] •Analysis of Paracetamol & Orphenadrine citrate in a combined dosage form by using Dual wavelength, Bivariate, Ratio difference, Ratio derivative and Mean centering of ratio spectra methods.•Analysis of Paracetamol & Caffeine in a combined dosage form by using Ratio difference, Ratio derivative and Mean centering of ratio spectra methods.•Analysis of Paracetamol & Diclofenac sodium in a combined dosage form by using Advanced absorption subtraction, Ratio difference, Ratio derivative and Mean centering of ratio spectra methods. but the editor asked me to reduce the number of words so the highlights were shrunk to one sentence.