Based on functional materials and PLGA for the florfenicol controlled release system and its antibacterial properties

It is widely used PLGA in synthesizing active drug nanoparticles due to its high biocompatibility, biodegradability, and pelletization. In this study with PLGA as the carrier, the florfenicol nanoparticles (FF-PLGA NPs) were investigated to improve water solubility and controlled drug release for achieving higher antibacterial activity. The nanoparticles were characterized by a particle analyzer and a transmission electron microscope. The size and morphology of the nanoparticles were all 80%) can achieve sustainable drug release in vitro. The addition of hydrophilic materials (2-HP-β-CD or PEG4000) to the FF-PLGA NPs improved drug solubility by about 3 and 2.5 times, respectively, and slowed down sudden release. The freeze-dried nanoparticles had high stability when stored at 4 °C. In vitro antibacterial test showed the antibacterial effects of the nanoparticle formulations on different strains were significantly improved compared with raw drugs. Hence, it is proved that PLGA as the carrier of the florfenicol nanoparticle delivery system is a new drug preparation with promising development prospects. [Display omitted] •FF-PLGA NPs with high entrapment efficiency and stability were obtained.•FF-PLGA NPs significantly prolonged drug release significantly compared to FF.•FF- PLGA NPs modified by hydrophilic materials can improve the solubility of drugs and reduce the burst effect.•Modified or not FF-PLGA NPs with or without modification have high biocompatibility and antibacterial activity.