Photo-controlled organocatalyzed radical polymerization synthesis of well-defined azlactone-functionalized polymers and its (bio)conjugated application

Well-defined azlactone-functionalized polymers have emerged as highly valuable precursors for the synthesis of (bio)molecules-conjugated materials. The development of polymerization process working at moderate temperature or ambient temperature and without use of metal catalysts or odorous agents for the synthesis of azlactone-functionalized polymers would be attractive, particularly in biomedical applications. In the present study, we have successfully copolymerized 2-vinyl-4,4-dimethylazlactone (VDM) and methacrylate monomers such as methyl methacrylate and poly(ethylene glycol) methyl ether methacrylate (mPEGMA) by photoinduced reversible complexed mediated polymerization (photo-RCMP). The polymerization was conducted at a wavelength of 365 nm and was well controlled with an initial ratio of VDM as high as of 20 mol%. The copolymer molecular weight and its dispersity (Ð