Contact hypersensitivity stomatitis in response to Suboxone use: A case report

AbstractContact hypersensitivity stomatitis is a type-4 hypersensitivity reaction of the oral mucosa. Suboxone is a sublingual film that combines buprenorphine and naloxone. In this report, we document the first case of contact hypersensitivity stomatitis in response to Suboxone, which led to a hospital admission. The patient was noted to have painful floor of mouth swelling and red-and-white lesions. Symptoms resolved after removal of the offending agent and treatment with IV and PO steroids. When patients present with floor of mouth edema, potentially concerning for an underlying sublingual space infection, it is important to perform a thorough review of potential medication side effects.