Endogenous oxygen-evolving bio-catalytic fabrics with fortified photonic disinfection for invasive bacteria-caused refractory cutaneous regeneration

Invasive bacterial infection interferes the normal orchestrated course of healing cascades during cutaneous regeneration. Hypoxia in the deep-seated infection microenvironment (IME) considerably precludes photonic disinfection efficacy, especially antibacterial photodynamic therapy (aPDT). Herein we develop IME-unlocked oxygen-evolving bio-catalytic fabrics composed of electrospun poly(ε-caprolactone) scaffolds, MXene/SnS2 bio-heterojunctions (MX/SnS bio-HJs), and lactate oxidase (LOx) for deep-seated bacteria-infected cutaneous regeneration. LOx can deplete lactic acid produced by bacteria at infected site and yield hydrogen peroxide (H2O2). The MX/SnS bio-HJs not only catalyze H2O2 to produce hydroxyl radicals (·OH) through Fenton-like reaction, but also generate oxygen (O2) to fortify aPDT under Near-infrared (NIR) light irradiation, consequently, expeditious disinfection is achieved. Moreover, in vivo results reveal that the bio-catalytic fabrics exert benign cutaneous regeneration ability by slaughtering bacteria, promoting hemostasis and collagen deposition. This work provides a tactic to instill fabrics with an IME-unlocked catalytic sterilization capability through endogenous O2 evolution for remedying infected wounds. [Display omitted] •An lactate-responsive bio-catalytic fabric was fabricated through electrospinning.•The bio-catalytic fabric generates O2 and H2O2 in IME, which can fortify PDT and CDT efficiency.•The fabric exerts benign photothermal effects and yields ROS upon NIR illumination.•The fabric promotes infected wound healing in vivo.