A previously unreported case of suppurative thrombophlebitis due to Clavispora lusitaniae

•We report a case of suppurative thrombophlebitis due to Clavispora lusitaniae.•Symptoms finally improved by a combination therapy of micafungin and flucytosine.•The therapy of micafungin and flucytosine did not rapidly resolve candidemia.•Caspofungin was reported to active against biofilms formed by C. lusitaniae.•Further study is desired to evaluate the therapy for C. lusitaniae biofilm. We report a case with Clavispora lusitaniae-induced purulent thrombophlebitis. The patient had multiple risk factors for the development of fungal thrombophlebitis including surgical procedure, mechanical ventilation, admission to intensive care unit, total parenteral nutrition and long-term antimicrobial therapy in addition to the insertion of central venous catheter. The symptoms finally improved by a combination therapy of micafungin and flucytosine, but the therapy did not rapidly resolve candidemia. The appropriate antifungal therapy for C. lusitaniae-induced purulent thrombophlebitis is uncertain. Further study is desired to seek the appropriate therapy for the disease.