Isolated cerebral mucormycosis associated with intravenous drug use

We present an uncommon case of isolated basal ganglia mucormycosis in a patient without any known cause of immunosuppression, but with a history of drug injection. The patient presented a good clinical and radiological response to antifungal treatment without aggressive surgical debridement (liposom...

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Veröffentlicht in:	Journal de mycologie médicale 2020-12, Vol.30 (4), p.101046, Article 101046
Hauptverfasser:	Durà-Miralles, X., Escolà-Vergé, L., Moreno, D., Martínez-Ricarte, F., Lung, M., Fernández-Hidalgo, N., Auger, C., Martín-Gómez, M.-T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - administration & dosage Basal ganglia Central Nervous System Fungal Infections - diagnosis Central Nervous System Fungal Infections - drug therapy Central Nervous System Fungal Infections - etiology Central Nervous System Fungal Infections - microbiology Cocaine Cocaine-Related Disorders - complications Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - microbiology Drug Therapy, Combination Drug Users Humans Isavuconazole Magnetic Resonance Imaging Male Marijuana Abuse - complications Marijuana Abuse - drug therapy Marijuana Abuse - microbiology Middle Aged Mucormycosis Mucormycosis - diagnosis Mucormycosis - drug therapy Mucormycosis - etiology Mucormycosis - microbiology Nitriles - administration & dosage Pyridines - administration & dosage Substance Abuse, Intravenous - complications Substance Abuse, Intravenous - diagnostic imaging Substance Abuse, Intravenous - drug therapy Substance Abuse, Intravenous - microbiology Triazoles - administration & dosage
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Beschreibung
Zusammenfassung:	We present an uncommon case of isolated basal ganglia mucormycosis in a patient without any known cause of immunosuppression, but with a history of drug injection. The patient presented a good clinical and radiological response to antifungal treatment without aggressive surgical debridement (liposomal amphotericin B combined with isavuconazole for 4 weeks followed by isavuconazole as maintenance therapy for 10 months).
ISSN:	1156-5233 1773-0449
DOI:	10.1016/j.mycmed.2020.101046