Revitalizing the nervous system: Exploring polypyrrole-based composites in nerve regeneration

Nerve regeneration faces different challenges i n clinical trials as a result of the poor healing ability of peripheral and central nerve systems. Conductive polymer-based scaffolds such as Polypyrrole (PPy) could improve nerve healing through electrical stimulation. However, the poor formability of PPy besides low degradability, etc. limited its applications. Thus, PPy-based composites are substituted as biocompatible, electro-conductive, and tunable degradable candidates to enhance PPy applications. The primary goals of the current review are the investigation of PPy-based composite structures, fabrication, and their characterization based on the recent cutting-edge articles. Moreover, the regeneration mechanism of nerve tissue is discussed to reveal the impact of PPy-based composites on nerve regeneration. Overall, this article reviewed the nerve reaeration merits of PPy-based composites besides the limitations. Eventually, the suggestive challenges and perspectives were considered to present a proper outlook for future research. [Display omitted]