An expedient access to aminoquinazolines and quinazolinones via N-atom insertion reaction using copper nano particles decorated on magnetic carbon spheres

The traditional catalytic materials for catalysis typically exhibit a lack of recyclability after the fresh cycle. Consequently, it is imperative to create materials that are more effective in recycling and reuse. Hence, this work presents a new sustainable method for producing copper nanoparticles...

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Veröffentlicht in:Materials today chemistry 2024-12, Vol.42, p.102395, Article 102395
Hauptverfasser: Thrilokraj, R., Khavatakoppa, Darshan, Hegde, Rajeev V., Małecki, Jan Grzegorz, Limaye, Akshay S., Kshirsagar, Umesh A., Ali, Raisuddin, Dateer, Ramesh B.
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Sprache:eng
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Zusammenfassung:The traditional catalytic materials for catalysis typically exhibit a lack of recyclability after the fresh cycle. Consequently, it is imperative to create materials that are more effective in recycling and reuse. Hence, this work presents a new sustainable method for producing copper nanoparticles decorated on magnetic carbon spheres (Cu@MCS) using reduction method for the first time. The authentication of the successful synthesis of Cu@MCS is confirmed using several analytical and spectroscopic characterization techniques. Additionally, an investigation was conducted to assess the catalytic efficiency of Cu@MCS for the synthesis of pharmaceutically significant 4-aminoquinazolines and quinazolinone derivatives. This study aimed to provide a cost-effective, sustainable, and base-free approach, eliminating the need for external ligands or additives under green solvent. The molecular complexation of the produced N-heterocycles and the effective synthesis of targets on a large scale have been achieved. In addition, the catalyst's recyclability and reuse by using external magnetic field, control studies, and the mechanistic elucidation of the processes were thoroughly examined. [Display omitted] •Development of copper nanoparticles decorated on Magnetic carbon spheres was demonstrated.•Synthesis of Cu@MCS in high yield and purity using simple reduction process.•Synthesis of N-heterocycles via nitrogen atom insertion using greener approach.•Synthetic utility of N-heterocycles and recyclability of catalyst was demonstrated.
ISSN:2468-5194
2468-5194
DOI:10.1016/j.mtchem.2024.102395