Development of TiO2-Based nanocomposite film for colorimetric detection of glucose

[Display omitted] •The anatase TiO2 nanocrystals with a diameter of 7.37 ± 2.31 nm were synthesized by the sol–gel method.•The TIC glucose biosensor has a dynamic range of 0.5–10 mM for reliable operation, with a detection limit of 0.4 mM.•Glucose biosensor based on TIC nanocomposite film is affordable, and easy to fabricate.•TIC film is an unexplored nanocomposite for non-enzymatic glucose sensing. This study proposes the development of a colorimetric non-enzymatic glucose sensor based on TiO2/I2/CMC (TIC) nanocomposite film. A solution-cast approach was employed for the synthesis of nanocomposite film. The structural and morphological study of the nanocomposite film was analyzed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transforms infrared (FTIR), Raman spectroscopy, photoluminescence, and dynamic light scattering. The XRD graph and Raman spectra indicate the synthesized nanocrystalline anatase form of TiO2 nanoparticles. The characteristic peak of Ti-O-Ti bonds is observed between 600 and 850 cm−1 in the FTIR spectrum. Additionally, TIC film exhibited antibacterial properties against E. coli and Bacillus subtilis. The colorimetric method was utilized to determine the glucose concentration. The TIC film reveals that the minimum detectable concentration is 0.4 mM. This easy-to-develop TIC nanocomposite film shows good stability. Therefore, it can be a promising candidate for glucose-sensing applications.