Rogue cell-like chromosomal aberrations in peripheral blood lymphocytes of interventional radiologists: A case study

•Rogue cell-like chromosomal aberrations were found in lymphocytes of radiologists.•Monitoring of medical staff during fluoroscopically-guided procedures is critical.•Radiation dose monitoring devices like ring or bracelet dosimeters may be helpful.•Periodic cytogenetic dosimetry ideal for screening...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mutation research. Genetic toxicology and environmental mutagenesis 2020-08, Vol.856-857, p.503234, Article 503234
Hauptverfasser: Jang, Seongjae, Lee, Younghyun, Seo, Songwon, Jin, Young Woo, Lee, Won-Jin
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•Rogue cell-like chromosomal aberrations were found in lymphocytes of radiologists.•Monitoring of medical staff during fluoroscopically-guided procedures is critical.•Radiation dose monitoring devices like ring or bracelet dosimeters may be helpful.•Periodic cytogenetic dosimetry ideal for screening of high-risk radiation workers. We report two cases of interventional radiologists who had been exposed to radiation while performing fluoroscopically-guided interventional procedures (FGIPs), mainly transcatheter arterial chemoembolization, percutaneous catheter drainage, and percutaneous transhepatic biliary drainage procedures, for over 10 years. They had a unique multi-aberrant cell type with not only high numbers of dicentrics and/or centric rings but also excess acentric double minutes, similar to a rogue cell. As revealed in a self-administered questionnaire, they wore personal dosimeters and protective equipment at all times and used shielding devices during interventional fluoroscopy procedures. However, the exposed dose levels derived from cytogenetic dosimetry were much higher than the doses recorded on their personal dosimeters. A large number of unstable and stable chromosomal aberrations that were found in the peripheral blood lymphocytes of these interventional radiologists might be due to repeated and long-term exposure to ionizing radiation while performing FGIPs. Further investigations of chromosomal aberrations in interventional radiologists may improve the understanding of the long-term effects of radiation exposure on medical personnel.
ISSN:1383-5718
1879-3592
DOI:10.1016/j.mrgentox.2020.503234